Publications

Discovery
A. Bashir, Q. Yang, J. Wang, S. Hoyer, W. Chou, C. McLean, G. Davis, Q. Gong, Z. Armstrong, J. Jang, H. Kang, A. Pawlosky, A. Scott, G. E. Dahl, M. Berndl, M. Dimon, B. S. Ferguson

Machine learning guided aptamer refinement and discovery

Nature Communications 12:2366 (2021)
J. Wang, J. Yu, Q. Yang, J. McDermott, A. Scott, M. Vukovich, R. Lagrois, Q. Gong, W. Greenleaf, M. Eisenstein, B. S. Ferguson, H. T. Soh

Multi-Parameter Particle Display (MPPD): A Quantitative Screening Method for Discovery of Highly Specific Aptamers

Angewandte Chemie International Edition 56 (3), 744-747 (2017)
H. Qu, A.T. Csordas, J. Wang, S-S Oh, M. Eisenstein, and H.T. Soh

Rapid and label-free strategy to select aptamers for metal ions

ACS Nano 10 (8), 7558-7565 (2016)
J. Wang, Q. Gong, N. Maheshwari, M. Eisenstein, M.L. Arcila, K.S. Kosik, H.T. Soh

Particle Display: A Quantitative Screening Method for Generating High-Affinity Aptamers

Angewandte Chemie International Edition 126 (19), 4896–4901 (2014)
Q. Gong, J. Wang, K. M. Ahmad, A. T. Csordas, J. Zhou, J. Nie, R. Stewart, J. Thomson, J. Rossi, and H. T. Soh

Selection Strategy to Generate Aptamer Pairs that Bind to Distinct Sites on Protein Target

Analytical Chemistry 84 (12), 5365−5371 (2012)
J. Wang, Y. Liu, T. Teesalu, K.N. Sugahara, V.R. Kotamraju, J.D. Adams, B.S. Ferguson, Q.Gong, S.S. Oh, A.T. Csordas, M. Cho, E. Ruoslahti, Y. Xiao, and H.T. Soh

Selection of Phage-Displayed Peptides on Live Adherent Cells in Microfluidic Channels

Proceedings of the National Academy of Sciences, USA. 108 (17), 6909-6914 (2011)
X. Lou, J. Qian, Y. Xiao, L. Viel, A.E. Gerdon, E.T. Lagally, P. Atzberger, T.M. Tarasow, A.J. Heeger, and H.T. Soh

Micromagnetic Selection of Aptamers in Microfluidic Channels

Proceedings of the National Academy of Sciences, USA. 106 (9), 2989-2994 (2009)
A. Csordas, A. Jorgensen, J. Wang, E. Gruber, Q. Gong, E. Bagley, M. Nakamoto, M. Eisenstein, and H.T. Soh

High-throughput discovery of aptamers for sandwich assays

Analytical Chemistry 88 (22), 10842–10847 (2016)
S. Meyer, J.P. Maufort, J. Nie, R. Stewart, B. McIntosh, L. Conti, K.M. Ahmad, H.T. Soh and J.A. Thomson

Development of an Efficient Targeted Cell-SELEX Procedure for DNA Aptamer Reagents

PLoS One 8 (8), e71798 (2013)
M. Cho, S.S. Oh, J. Nie, R. Stewart, M.S. Eisenstein, J. Chambers, J.D. Marth, F. Walker, J.A. Thomson, H.T. Soh

Quantitative Selection and Parallel Characterization of Aptamers

Proceedings of the National Academy of Sciences, USA. 110 (46), 18460-18465 (2013)
K. Ahmad, Y. Xiao and H.T. Soh

Selection is More Intelligent than Design: Improving the Affinity of a Bivalent Ligand through Directed Evolution

Nucleic Acids Research 40 (22), 11777-11783 (2012)
J. Wang, J.F. Rudzinski, Q. Gong, H. T. Soh, P.J. Atzberger

Influence of Target Concentration and Background Binding on In Vitro Selection of Affinity Reagents,

PLoS One 7 (8), e43940 (2012)
M. Cho, Y. Xiao, J. Nie, R. Stewart, A. Csordas, S. S. Oh, J. Thomson, H. T. Soh

Quantitative Selection of DNA Aptamers through Microfluidic Selection and High Throughput Sequencing

Proceedings of the National Academy of Sciences, USA. 107 (35), 15373-15378 (2010)
Biosensing
P.L. Mage, B.S. Ferguson, D. Maliniak, K.L Ploense, T.E. Kippin and H.T. Soh

Closed-loop control of circulating drug levels in live animals

Nature Biomedical Engineering 1, 70 (2017)
B.S. Ferguson, D.A. Hoggarth, D. Maliniak, K. Ploense, R.J. White, N. Woodward, K. Hsieh, A.J. Bonham, M. Eisenstein, T. Kippin, K.W. Plaxco and H.T. Soh

Real-time, aptamer-based tracking of circulating therapeutic agents in living animals

Science Translational Medicine 5, 213ra165 (2013)
S.S. Oh, K. Plaxco, Y. Xiao, M. Eisenstein, and H.T. Soh

In Vitro Selection of Shape-Changing DNA Nanostructures Capable of Binding-Induced Cargo Release

ACS Nano 7 (11), 9675–9683 (2013)
I. Olmsted, Y. Xiao, M. Cho, A. Csordas, J. Sheehan, J. Meiler, H. T. Soh, and D. Bornhop

Measurement of Aptamer-Protein Interactions with Back-Scattering Interferometry

Analytical Chemistry 83 (23), 8867-8870 (2011)
B.S. Ferguson, S.F. Buchsbaum, T.T. Wu, K. Hsieh, Y. Xiao, R. Sun and H.T. Soh

Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care Diagnostics

Journal of the American Chemical Society 133 (23), 9129-9135 (2011)
A. Csordas, A.E. Gerdon, J.D. Adams, J. Qian, S.S. Oh, Y. Xiao, and H.T. Soh

Detection of Proteins in Serum via Micromagnetic Aptamer PCR (MAP) Technology

Angewandte Chemie International Edition 49 (2), 355-358 (2010)
B.S. Ferguson, S. Buchsbaum, J. Swensen, K. Hsieh, X.H. Lou, and H.T. Soh

Integrated Microfluidic Electrochemical DNA Sensor

Analytical Chemistry 81 (15), 6503-6508 (2009)
J. Swensen, Y. Xiao, B.S. Ferguson, A. Lubin, R. Lai, A.J Heeger, K.W. Plaxco, and H.T. Soh

Continuous Real-Time Monitoring of Cocaine in Undiluted Blood Serum via a Microfluidic Electrochemical Aptamer-Based Sensor

Journal of the American Chemical Society 131 (12), 4262-4266 (2009)